How to Use DEFINITY®: Dosing and Administration
Administration Options and Supplies Needed
Activated DEFINITY® can be administered in different ways to suit the needs of the clinical application.
It is important that aseptic procedures are adhered to throughout the preparation and administration process of activated DEFINITY®.
| Dosing Option |
Benefits |
| IV Bolus1 |
- Administer 10 µL/kg of activated DEFINITY® by slow IV injection over 30-60 seconds (to reduce attenuation artifacts)
- Follow with a 10 mL preservative-free saline flush
- Maximum allowable dose of activated DEFINITY® is 20 µL/kg
- If necessary, a second 10 µL/kg dose followed by a second saline flush can be administered 30 minutes after first injection.
|
| Continuous IV Infusion1 |
- Add 1.3 mL activated DEFINITY® to 50 mL of preservative-free saline
- Gently squeeze IV bag to evenly distribute microspheres
- Initiate at 4.0 mL/minute; maximum 10.0 mL/minute
- Adjust flow rate for optimal image enhancement
|
| Diluted IV Bolus* |
- 1.3 mL of activated DEFINITY® diluted with 8.7 mL of preservative-free saline in a 10-cc syringe
- Initial injection of up to 3 mL administered slowly (subsequent injection of 1 to 2 mL as needed)
- Better suited for low MI non-linear imaging
*This method of dosing and administration is within the dosing range and administration type listed in the DEFINITY® Package Insert |
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- DEFINITY® US Package Insert.
